Highly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy
نویسندگان
چکیده
منابع مشابه
Fabrication of poly-DL-lactide/polyethylene glycol scaffolds using the gas foaming technique.
The aim of this study was to prepare poly-DL-lactide/polyethylene glycol (PDLLA/PEG) blends to improve medium absorption and cell proliferation in the three-dimensional (3-D) structure of their scaffolds. Carbon dioxide (CO2) was used as a foaming agent to create porosity in these blends. The results of Fourier transform infrared (FTIR) spectroscopy demonstrated that the blends were homogeneous...
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For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of cl...
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The effects of blend weight ratio and polyester block length of methoxy poly(ethylene glycol)-b-poly( d, l-lactide) (MPEG- b-PDLL)/methoxy poly(ethylene glycol)- b-poly(ϵ-caprolactone) (MPEG- b-PCL) blends on nanoparticle characteristics and drug release behaviors were evaluated. The blend nanoparticles were prepared by nanoprecipitation method for controlled release of a poorly water-soluble m...
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متن کامل
Angiogenic and Osteogenic Coupling Effects of Deferoxamine-Loaded Poly(lactide-co-glycolide)-Poly(ethylene glycol)-Poly(lactide-co-glycolide) Nanoparticles
Angiogenesis and osteogenesis coupling processes are essential for bone regeneration, and human bone marrow stromal cells (hBMSCs) along with endothelial cells (ECs) are crucial participants. Deferoxamine (DFO), a hypoxia-mimetic agent, could activate the hypoxia-inducible factor (HIF)-1α signaling pathway and trigger angiogenic and osteogenic effects in these cells. However, the lifetime of DF...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2020
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2020.1716875